13. NONCLINICAL TOXICOLOGY

"at the end of this leaflet.What should I tell my doctor before taking sildenafil tablets?Tell your doctor about all of your medical conditions, including if youhave heart problems such as angina (chest pain), heart failure, irregular heartbeats, or have had a heart attackhave a disease called pulmonary veno-occlusive disease (PVOD)have high or low blood pressure or blood circulation problemshave an eye problem called retinitis pigmentosahave or had loss of sight in one or both eyeshave any problem with the shape of your penis or Peyronie's diseasehave any blood cell problems such sickle cell anemiahave a stomach ulcer or any bleeding problemsare pregnant or planning to become pregnant. Sildenafil passes into your breast milk or if it could harm your baby.Tell your doctor about all of the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal products.Sildenafil tablets and certain other medicines can cause side effects if you take them together. "Ritonavir (Norvir ®) or other medicines used to treat HIV infectionKetoconazole (Nizoral ®)Itraconazole (Sporanox)High blood pressure medicineKnow the medicines you take. Keep a list of your medicines and show it to your doctor and pharmacist when you get a new medicine.How should I take sildenafil tablets?Take sildenafil tablets exactly as your doctor tells you.Sildenafil tablets may be prescribed to you asSildenafil tabletsTake sildenafil tablets 3 times a day about 4 to 6 hours apart.Take sildenafil tablets at the same times every day.If you miss a dose, take it as soon as you remember. Talk to your doctor first.If you take too much sildenafil tablets, call your doctor or go to the nearest hospital emergency room.What are the possible side effects of sildenafil tablets?low blood pressure.Low blood pressure may cause you to feel faint or dizzy. Lie down if you feel faint or dizzy.more shortness of breath than usual.Tell your doctor if you get more short of breath after you start sildenafil tablets. More shortness of breath than usual may be due to your underlying medical condition.decreased eyesight or loss of sight in one or both eyes (NAION).If you notice a sudden decrease or loss of eyesight, talk to your doctor right away.sudden decrease or loss of hearing.If you notice a sudden decrease or loss of hearing, talk to your doctor right away.

16. How is Sildenafil Tablets supplied

Tell your doctor if you have any side effect that bothers you or doesn't go away. You may report side effects to FDA at 1-800-FDA-1088 Store sildenafil tablets at controlled room temperature, between 20°C -25°C (68°F -77°F). PRINCIPAL DISPLAY PANEL - 20 mg Tablet Bottle Label You’re thinking of taking sildenafil or maybe you’re already taking it. It’s really important that you understand your dosage options. Taking the right dose for you can improve your results and minimize your chances of side effects.

7.2 Alpha-blockers

That’s the thing, everybody is different – it’s about getting the right dose for you. You’ve probably thought about increasing your dose to get what you think are better results – we know, you want to last longer too. However, you shouldn’t change your dose yourself. You should always listen to the medical professional that prescribes it to you and take your dose as they direct. Sildenafil pills come in three doses, 25 mg, 50 mg and 100 mg.

Common Side Effects

The mg stands for milligrams (one thousandth of a gram) and is the amount of active ingredient (sildenafil citrate) in the pill. Viagra has the same active ingredient as sildenafil, meaning it works in the same way. Viagra has the same dosage options as sildenafil, which contains the same amount of the active ingredient. As above, a 25 mg Viagra pill contains a sildenafil citrate dosage of 25 mg. How you react to different doses will depend on factors including your physical condition, what other medications you’re taking, your lifestyle and how your unique biology reacts to the drug. It is not possible to determine whether these events are related directly to this class of oral medicines, including sildenafil tablets, or to other diseases or medicines, to other factors, or to a combination of factors.heart attack, stroke, irregular heartbeats, and death.Most of these happened in men who already had heart problems.erections that last several hours.If you have an erection that lasts more than 4 hours, get medical help right away. If it is not treated right away, priapism can permanently damage your penis.The most common side effects with sildenafil tablets include:Nosebleed, headache, upset stomach, getting red or hot in the face (flushing), trouble sleeping, as well as fever, erection increased respiratory infection, nausea, vomiting, bronchitis, pharyngitis, runny nose, and pneumonia in children.Tell your doctor if you have any side effect that bothers you or doesn't go away.These are not all the possible side effects of sildenafil tablets. You may report side effects to FDA at 1-800-FDA-1088How should I store sildenafil tablets?Store sildenafil tablets at controlled room temperature, between 20°C -25°C (68°F -77°F).Keep Sildenafil tablets and all medicines away from children.General information about sildenafil tabletsMedicines are sometimes prescribed for purposes that are not in the patient leaflet. If you would like more information about sildenafil tablets talk with your doctor.

You can ask your doctor or pharmacist for information about sildenafil tablets that is written for health professionals.What are the ingredients in sildenafil tablets?Active ingredients:sildenafil citrateInactive ingredients: Crospovidone, Hypromellose, Hydrophobic colloidal silica, Lactose monohydrate, Magnesium stearate, Microcrystalline cellulose, Titanium dioxide, and Triacetin.This Patient Information has been approved by the U.S. Food and Drug Administration. Nitroglycerin in any form including tablets, patches, sprays, and ointments Street drugs called "poppers" (amyl nitrate or nitrite) Ask your doctor or pharmacist if you are not sure if you are taking a nitrate or a guanylate cyclase stimulator medicine. Sildenafil tablets are prescription medicine used in adults to treat pulmonary arterial hypertension (PAH). Sildenafil tablets are not for use in children Adding sildenafil tablets to another medication used to treat PAH, bosentan (Tracleer®), does not result in improvement in your ability to exercise. Sildenafil tablets contain the same medicine as VIAGRA ®(sildenafil), which is used to treat erectile dysfunction (impotence). Do not take sildenafil tablets if you: See " What is the most important information I should know about Sildenafil tablets?" See " What is the most important information I should know about sildenafil tablets?" are allergic to sildenafil or any other ingredient in sildenafil tablets. Tell your doctor about all of your medical conditions, including if you have heart problems such as angina (chest pain), heart failure, irregular heartbeats, or have had a heart attack have a disease called pulmonary veno-occlusive disease (PVOD) have high or low blood pressure or blood circulation problems have an eye problem called retinitis pigmentosa have or had loss of sight in one or both eyes have any problem with the shape of your penis or Peyronie's disease have any blood cell problems such sickle cell anemia have a stomach ulcer or any bleeding problems are pregnant or planning to become pregnant. Sildenafil passes into your breast milk or if it could harm your baby.

• The usual starting dose of sildenafil for ED is 50 mg, but 20 mg may be prescribed for some patients.
• Prescription requirements ensure safe usage and proper dosing based on health conditions.
• Always follow a doctor’s instructions when taking sildenafil 20 mg.

Tell your doctor about all of the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal products.Sildenafil tablets and certain other medicines can cause side effects if you take them together. Especially tell your doctor if you take See " What is the most important information I should know about sildenafil tablets?" Ritonavir (Norvir ®) or other medicines used to treat HIV infection Keep a list of your medicines and show it to your doctor and pharmacist when you get a new medicine. Sildenafil tablets may be prescribed to you as Take sildenafil tablets 3 times a day about 4 to 6 hours apart. low blood pressure.Low blood pressure may cause you to feel faint or dizzy.

Drug Label Information

"at the end of this leaflet.What should I tell my doctor before taking sildenafil tablets?Tell your doctor about all of your medical conditions, including if youhave heart problems such as angina (chest pain), heart failure, irregular heartbeats, or have had a heart attackhave a disease called pulmonary veno-occlusive disease (PVOD)have high or low blood pressure or blood circulation problemshave an eye problem called retinitis pigmentosahave or had loss of sight in one or both eyeshave any problem with the shape of your penis or Peyronie's diseasehave any blood cell problems such sickle cell anemiahave a stomach ulcer or any bleeding problemsare pregnant or planning to become pregnant. Sildenafil passes into your breast milk or if it could harm your baby.Tell your doctor about all of the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal products.Sildenafil tablets and certain other medicines can cause side effects if you take them together. "Ritonavir (Norvir ®) or other medicines used to treat HIV infectionKetoconazole (Nizoral ®)Itraconazole (Sporanox)High blood pressure medicineKnow the medicines you take. Keep a list of your medicines and show it to your doctor and pharmacist when you get a new medicine.How should I take sildenafil tablets?Take sildenafil tablets exactly as your doctor tells you.Sildenafil tablets may be prescribed to you asSildenafil tabletsTake sildenafil tablets 3 times a day about 4 to 6 hours apart.Take sildenafil tablets at the same times every day.If you miss a dose, take it as soon as you remember. Talk to your doctor first.If you take too much sildenafil tablets, call your doctor or go to the nearest hospital emergency room.What are the possible side effects of sildenafil tablets?low blood pressure.Low blood pressure may cause you to feel faint or dizzy.

How sildenafil is used

Lie down if you feel faint or dizzy.more shortness of breath than usual.Tell your doctor if you get more short of breath after you start sildenafil tablets. More shortness of breath than usual may be due to your underlying medical condition.decreased eyesight or loss of sight in one or both eyes (NAION).If you notice a sudden decrease or loss of eyesight, talk to your doctor right away.sudden decrease or loss of hearing.If you notice a sudden decrease or loss of hearing, talk to your doctor right away. It is not possible to determine whether these events are related directly to this class of oral medicines, including sildenafil tablets, or to other diseases or medicines, to other factors, or to a combination of factors.heart attack, stroke, irregular heartbeats, and death.Most of these happened in men who already had heart problems.erections that last several hours.If you have an erection that lasts more than 4 hours, get medical help right away. If it is not treated right away, priapism can permanently damage your penis.The most common side effects with sildenafil tablets include:Nosebleed, headache, upset stomach, getting red or hot in the face (flushing), trouble sleeping, as well as fever, erection increased respiratory infection, nausea, vomiting, bronchitis, pharyngitis, runny nose, and pneumonia in children.Tell your doctor if you have any side effect that bothers you or doesn't go away.These are not all the possible side effects of sildenafil tablets. You may report side effects to FDA at 1-800-FDA-1088How should I store sildenafil tablets?Store sildenafil tablets at controlled room temperature, between 20°C -25°C (68°F -77°F).Keep Sildenafil tablets and all medicines away from children.General information about sildenafil tabletsMedicines are sometimes prescribed for purposes that are not in the patient leaflet.

Revatio for Oral Suspension

If you would like more information about sildenafil tablets talk with your doctor. You can ask your doctor or pharmacist for information about sildenafil tablets that is written for health professionals.What are the ingredients in sildenafil tablets?Active ingredients:sildenafil citrateInactive ingredients: Crospovidone, Hypromellose, Hydrophobic colloidal silica, Lactose monohydrate, Magnesium stearate, Microcrystalline cellulose, Titanium dioxide, and Triacetin.This Patient Information has been approved by the U.S. Food and Drug Administration. Nitroglycerin in any form including tablets, patches, sprays, and ointments Street drugs called "poppers" (amyl nitrate or nitrite) Ask your doctor or pharmacist if you are not sure if you are taking a nitrate or a guanylate cyclase stimulator medicine. Sildenafil tablets are prescription medicine used in adults to treat pulmonary arterial hypertension (PAH). more shortness of breath than usual.Tell your doctor if you get more short of breath 50 mg sildenafil price after you start sildenafil tablets. decreased eyesight or loss of sight in one or both eyes (NAION).If you notice a sudden decrease or loss of eyesight, talk to your doctor right away. sudden decrease or loss of hearing.If you notice a sudden decrease or loss of hearing, talk to your doctor right away.

• Common side effects of sildenafil include headaches, flushing, and nasal congestion.
• Serious side effects are rare but require immediate medical attention.
• Patients should report any adverse reactions to their healthcare provider.

heart attack, stroke, irregular heartbeats, and death.Most of these happened in men who already had heart problems. erections that last several hours.If you have an erection that lasts more than 4 hours, get medical help right away. The most common side effects with sildenafil tablets include: Nosebleed, headache, upset stomach, getting red or hot in the face (flushing), trouble sleeping, as well as fever, erection increased respiratory infection, nausea, vomiting, bronchitis, pharyngitis, runny nose, and pneumonia in children.

• Sildenafil 20 mg tablets should be taken about 30 to 60 minutes before sexual activity.
• It’s important not to take more than one dose in 24 hours.
• Do not crush or chew the medication; swallow it whole with water.

Tell your doctor if you have any side effect that bothers you or doesn't go away.

5.3 Worsening Pulmonary Vascular Occlusive Disease

Sildenafil tablets are not for use in children Adding sildenafil tablets to another medication used to treat PAH, bosentan (Tracleer®), does not result in improvement in your ability to exercise. Sildenafil tablets contain the same medicine as VIAGRA ®(sildenafil), which is used to treat erectile dysfunction (impotence). Do not take sildenafil tablets if you: See " What is the most important information I should know about Sildenafil tablets?" See " What is the most important information I should know about sildenafil tablets?" are allergic to sildenafil or any other ingredient in sildenafil tablets. Tell your doctor about all of your medical conditions, including if you have heart problems such as angina (chest pain), heart failure, irregular heartbeats, or have had a heart attack have a disease called pulmonary veno-occlusive disease (PVOD) have high or low blood pressure or blood circulation problems have an eye problem called retinitis pigmentosa have or had loss of sight in one or both eyes have any problem with the shape of your penis or Peyronie's disease have any blood cell problems such sickle cell anemia have a stomach ulcer or any bleeding problems are pregnant or planning to become pregnant. Sildenafil passes into your breast milk or if it could harm your baby.

Sildenafil Tablets or Oral Suspension for PAH

Tell your doctor about all of the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal products.Sildenafil tablets and certain other medicines can cause side effects if you take them together. Especially tell your doctor if you take See " What is the most important information I should know about sildenafil tablets?" Ritonavir (Norvir ®) or other medicines used to treat HIV infection Keep a list of your medicines and show it to your doctor and pharmacist when you get a new medicine. Sildenafil tablets may be prescribed to you as Take sildenafil tablets 3 times a day about 4 to 6 hours apart. low blood pressure.Low blood pressure may cause you to feel faint or dizzy. more shortness of breath than usual.Tell your doctor if you get more short of breath 50 mg sildenafil price after you start sildenafil tablets.

Why it’s used

decreased eyesight or loss of sight in one or both eyes (NAION).If you notice a sudden decrease or loss of eyesight, talk to your doctor right away. sudden decrease or loss of hearing.If you notice a sudden decrease or loss of hearing, talk to your doctor right away. heart attack, stroke, irregular heartbeats, and death.Most of these happened in men who already had heart problems. erections that last several hours.If you have an erection that lasts more than 4 hours, get medical help right away. The most common side effects with sildenafil tablets include: Nosebleed, headache, upset stomach, getting red or hot in the face (flushing), trouble sleeping, as well as fever, erection increased respiratory infection, nausea, vomiting, bronchitis, pharyngitis, runny nose, and pneumonia in children. You may report side effects to FDA at 1-800-FDA-1088 Store sildenafil tablets at controlled room temperature, between 20°C -25°C (68°F -77°F). PRINCIPAL DISPLAY PANEL - 20 mg Tablet Bottle Label You’re thinking of taking sildenafil or maybe you’re already taking it. It’s really important that you understand your dosage options. Taking the right dose for you can improve your results and minimize your chances of side effects. That’s the thing, everybody is different – it’s about getting the right dose for you. You’ve probably thought about increasing your dose to get what you think are better results – we know, you want to last longer too. However, you shouldn’t change your dose yourself. You should always listen to the medical professional that prescribes it to you and take your dose as they direct. Sildenafil pills come in three doses, 25 mg, 50 mg and 100 mg. The mg stands for milligrams (one thousandth of a gram) and is the amount of active ingredient (sildenafil citrate) in the pill. Viagra has the same active ingredient as sildenafil, meaning it works in the same way.

• Alcohol can interact with sildenafil, reducing its effectiveness and increasing side effects.
• Avoid alcohol consumption when planning to use sildenafil.
• Always inform your doctor about alcohol use prior to prescription.

Viagra has the same dosage options as sildenafil, which contains the same amount of the active ingredient. As above, a 25 mg Viagra pill contains a sildenafil citrate dosage of 25 mg.

5.4 Visual Loss

But generally speaking, stronger doses of sildenafil will increase your chances of getting and maintaining an erection. A stronger dose won’t give you a longer-lasting erection or otherwise enhance your sexual performance, it just improves your chances of overcoming ED. But stronger doses also increase your chances of side effects. These tend to be mild and short-lasting, but they can be more serious. This means finding the right dose of sildenafil for you is a balancing act.

Looking for a Different Strength?

You want a dose that works for your erections and that doesn’t give you any side effects that you can’t tolerate. Most men who take sildenafil don’t experience side effects or if they do they are relatively mild and short-lasting. The most common side effects of sildenafil include headaches, hot flushes, indigestion, a blocked nose, blurred vision and color changes to your vision, like a blue tint. In rarer cases, sildenafil can cause more serious side effects. How you react to different doses will depend on factors including your physical condition, what other medications you’re taking, your lifestyle and how your unique biology reacts to the drug. But generally speaking, stronger doses of sildenafil will increase your chances of getting and maintaining an erection. A stronger dose won’t give you a longer-lasting erection or otherwise enhance your sexual performance, it just improves your chances of overcoming ED. But stronger doses also increase your chances of side effects. These tend to be mild and short-lasting, but they can be more serious. This means finding the right dose of sildenafil for you is a balancing act. You want a dose that works for your erections and that doesn’t give you any side effects that you can’t tolerate. Most men who take sildenafil don’t experience side effects or if they do they are relatively mild and short-lasting. The most common side effects of sildenafil include headaches, hot flushes, indigestion, a blocked nose, blurred vision and color changes to your vision, like a blue tint. In rarer cases, sildenafil can cause more serious side effects.