Understanding Dapoxetine 30mg for Premature Ejaculation

McMahon's study in 2012 showed that dapoxetine has no effect on mood and is not associated with anxiety or suicidality. The incidence of antidepressant discontinuation syndrome symptoms in men using dapoxetine to treat PE has been described by reviewers as low or no different from the incidence of such symptoms in men withdrawn from placebo treatment.

Further information

It is more rapidly absorbed and mostly eliminated from the body within a few hours. These pharmacokinetics are more favorable in that they might minimize drug accumulation in the body, habituation, and side effects. Dapoxetine was initially considered unsuccessful in its intended use as an antidepressant; however, it has since been investigated as a possible aid to an approach to depression treatment focused on stress reduction, based on an animal model of depression. Dapoxetine should not be used in men with moderate to severe hepatic impairment and in those receiving CYP3A4 inhibitors such as ketoconazole, ritonavir, and telithromycin. Dapoxetine also cannot be used in patients with heart failure, permanent pacemaker, or other significant ischemic heart disease.

Check with your doctor if:

Caution is advised in men receiving thioridazine, monoamine oxidase inhibitors, SSRIs, serotonin-norepinephrine reuptake inhibitors, or tricyclic antidepressants. If a patient stops taking one of these drugs, he should wait for 14 days before taking dapoxetine. If a patient stops taking dapoxetine, he should wait for 7 days before receiving these drugs. The most common effects when taking dapoxetine are nausea, dizziness, dry mouth, headache, diarrhea, and insomnia. [16][17] Discontinuation rates due to adverse effects and costs are very high, as demonstrated in a study dapoxetine tadalafil tablets in Asia which showed that cumulative discontinuation rates within one year are as high as 87%. [33][34] The lack of chronic serotonergic stimulation with on-demand dapoxetine minimizes the potentiation action of serotonin at synaptic cleft, thus decreasing the risk of discontinuation symptoms.

• Dapoxetine 30mg is primarily used to treat premature ejaculation in men.
• It belongs to a class of medications called selective serotonin reuptake inhibitors (SSRIs).
• The tablet is typically taken 1 to 3 hours before sexual activity.
• It works by increasing serotonin levels to help delay ejaculation.
• Dapoxetine is fast-acting and has a short half-life compared to other SSRIs.
• Common side effects include nausea, dizziness, headache, and dry mouth.
• This medication should not be taken with alcohol or recreational drugs.
• It requires a prescription and should be used under medical supervision.

Currently, very few methods are used to synthesize (S)-dapoxetine. This novel approach consists of only six steps in which three main steps are shown above.

Product	Dosage	Quantity + Bonus	Price
Priligy Generic Dapoxetine	60mg	120 + 10 Pills	341.26€ 325.01€	Buy
Viagra Professional	100mg	360 + 6 Pills	527.09€ 501.99€	Buy
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Levitra Generic	10mg	30 + 4 Pills	62.39€ 59.42€	Buy
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Cialis Generic	60mg	30 + 2 Pills	85.33€ 81.27€	Buy
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Priligy Generic Dapoxetine	60mg	20 + 4 Pills	77.31€ 73.63€	Buy
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Priligy Generic Dapoxetine	60mg	90 + 10 Pills	265.64€ 252.99€	Buy

The initial reactant is trans-cinnamyl alcohol, which vardenafil with dapoxetine tablets is commercially available.

Age Range	Typical User Profile	Notes
18-45 years	Younger men seeking to delay ejaculation	Most common demographic
46-65 years	Ageing men with premature ejaculation issues	Less common, consult doctor
Special populations	Athletes, performers	Off-label use, caution advised

Sharpless asymmetric epoxidation and Mitsunobu reaction have been used to produce expected (S)-dapoxetine. This method is considered a good choice compared to the known methods due to high yield and easily obtainable reactants. Dapoxetine was created by Eli Lilly and in phase I clinical trial as an antidepressant.

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Phase I trials showed that dapoxetine had neither clinically significant electrocardiographic effects nor delayed repolarization effects, with dosing up to four-fold greater than the maximum recommended dosage, which is 60 mg. Phase III studies in men with PE showed a safety and well tolerated profile of dapoxetine with dosing of 30 and 60 mg. No cardiovascular adverse had been found. Studies of SSRIs in patients with major psychiatric disorders prove that SSRIs are potentially associated with certain neurocognitive adverse effects such as anxiety, akathisia, hypomania, changes in mood, or suicidal thought. [30][31] No study on the effects of SSRIs in men with PE has been done. It never worked out well as a medication for the treatment of depression, though, and was shelved for a while before subsequently developed to treat PE. In December 2003, Eli Lilly sold the patent for dapoxetine to Pharmaceutical Product Development (PPD) for US$65 million.

Safety Advices

Its initial half-life is 1.31 hours (30 mg dose) and 1.42 hours (60 mg dose), and its terminal half life is 18.7 hours (30 mg dose) and 21.9 hours (60 mg dose). Dapoxetine is metabolized extensively in the liver and kidney by multiple enzymes such as CYP2D6, CYP3A4, and flavin monooxygenase 1. The major product at the end of the metabolic pathway is circulating dapoxetine N-oxide, which is a weak SSRI and contributes no clinical effect. The metabolites of dapoxetine are eliminated rapidly in the urine with a terminal half-life of 18.7 and 21.9 hours for a single dose of 30 mg and 60 mg, respectively. The cardiovascular safety profile of dapoxetine has been studied extensively during the drug development. Eli Lilly may also receive royalties payment from PPD if the sale exceeds a certain amount. Research into the effectiveness of dapoxetine was revisited in 2020.

What Is Dapoxetine 30mg?

The mechanism through which dapoxetine affects premature ejaculation is still unclear, but dapoxetine is presumed to work by inhibiting serotonin transporter (SERT) and subsequently increasing serotonin's action at pre- and postsynaptic receptors. [22] Human ejaculation is regulated by various areas in the central nervous system (CNS). These signals are passed on to the brain stem, which then is influenced by a number of nuclei in the brain such as medial preoptic and paraventricular nuclei. [24] Clement's study performed on anaesthetized male rats showed that acute administration of dapoxetine inhibits ejaculatory expulsion reflex at supraspinal level by modulating activity of lateral paragigantocellular nucleus (LPGi) neurons. These effects cause an increase in pudendal motoneuron reflex discharge (PMRD) latency, though whether dapoxetine acts directly on LPGi or on the descending pathway in which LPGi located is unclear.

Brand Names

Dapoxetine is a white, powdery, water-insoluble substance. Taken one to three hours before sexual activity, it is rapidly absorbed in the body. Its maximum plasma concentration (Cmax) is reached one to two hours after oral administration. The Cmax and AUC (area under the plasma vs. time curve) is dose dependent. ALZA is the current owner of dapoxetine, but PPD will receive milestone payments and drug royalties from ALZA.

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The Cmax and Tm (time needed to obtain the maximum plasma concentration) after single doses of dapoxetine 30 mg and 60 mg are 297 and 498 ng/ml at 1.01 and 1.27 hours, respectively. A high-fat meal does reduce the Cmax slightly, but it is insignificant. It can be taken with or without food. Dapoxetine is absorbed and distributed rapidly in the body. The mean steady-state volume is 162 L. If approved, dapoxetine will be marketed in the US by Ortho McNeil pharmaceutical, Inc. Ortho McNeil and Janssen-Ortho Inc, or Janssen-Cilag are all units of Johnson & Johnson.

• Discontinuation rates in studies are often due to side effects.
• Nausea is the most common reason for stopping.
• Taking the tablet with a light snack may reduce nausea.
• Dizziness can be mitigated by rising slowly from sitting.
• Headaches may be managed with simple analgesics.
• If side effects are intolerable, the drug should be stopped.
• A lower dose is not available below 30mg.
• Therefore, discontinuation is the only option if 30mg is not tolerated.
• Most side effects are mild to moderate and transient.
• They often diminish with continued use.
• However, continued use does not mean daily use.
• Tolerance to the therapeutic effect does not develop.

As at 2005, dapoxetine was in phase III clinical trials, pending review by the FDA.

• It is important to distinguish PE from other dysfunctions.
• Rapid ejaculation with loss of erection may indicate ED.
• A thorough medical and sexual history is critical.
• Physical examination may rule out anatomical issues.
• Laboratory tests are not routinely required.
• Thyroid function tests may be done if symptoms suggest.
• Neurological examination is rarely needed.
• The condition is common, affecting 20-30% of men.
• Despite being common, many men do not seek help.
• Stigma remains a significant barrier to treatment.
• Dapoxetine's approval helped legitimize PE as a treatable condition.
• Public awareness campaigns aim to reduce stigma.

Dapoxetine has been marketed and approved in more than 50 countries. [39] Dapoxetine has been approved in Italy, Spain, Mexico, South Korea, and New Zealand in 2009 and 2010; marketed in Sweden, Austria, Germany, Finland, Spain, Portugal, and Italy.

Region	Average Cost per Pack	Availability	Additional Notes
North America	$50 - $120	Widely available via prescription	Insurance may cover or not
Europe	€40 - €100	Prescribed in clinics	Generic options often available
Asia	$10 - $40	Over-the-counter in some countries	Varies by local regulations

It has also been approved in France, Russia, Malaysia, Philippines, Argentina, and Uruguay. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese).

2. What should I know before I take PRILIGY?

[18] Unlike other SSRIs used to treat depression, which have been associated with high incidences of sexual dysfunction,[19] dapoxetine is associated with low rates of sexual dysfunction. Taken as needed, dapoxetine has very mild adverse effects of decreased libido (<1%) and erectile dysfunction (<4%). No case of drug overdose has been reported during clinical trials. Many men who have PE also suffer from erectile dysfunction (ED). Treatment for these patients should consider the drug–drug interaction between dapoxetine and PDE5 inhibitors such as tadalafil (Cialis) or sildenafil (Viagra).

Generic Names

In Dresser study (2006), plasma concentration of 24 subjects was obtained. Half of the sample pool were treated with dapoxetine 60 mg plus tadalafil 20 mg; the other half were treated with dapoxetine 60 mg plus sildenafil 100 mg. These plasma samples were then analyzed using liquid chromatography-tandem mass spectrometry. The results showed that dapoxetine does not alter the pharmacokinetics of tadalafil or sildenafil. Alcohol does not affect the pharmacokinetics of dapoxetine when taking concurrently. Archived from the original on 2023-08-03.

• Dapoxetine 30mg was approved in many countries specifically for premature ejaculation.
• Research shows it improves sexual satisfaction and reduces performance anxiety.
• Step-by-step instructions should be followed for optimal effectiveness.
• Do not exceed the prescribed dose to avoid adverse effects.
• The tablet should be swallowed whole with water; not to be crushed or chewed.
• Dapoxetine does not provide contraceptive effects or protect against STDs.
• Regular medical check-ups recommended during prolonged use.
• Discuss any mental health changes with your doctor during treatment.

"Dapoxetine, a novel treatment for premature ejaculation, does not have pharmacokinetic interactions with phosphodiesterase-5 inhibitors".

Brand Name	Manufacturer	Typical Price Range	Notes
Priligy	Johnson & Johnson	$70 - $120 per pack	Original branded version
Generic Dapoxetine	Various manufacturers	$20 - $60 per pack	Usually more affordable
Other Brands	Local pharmaceutical companies	Varies	Availability depends on country

"Dapoxetine: a new option in the medical management of premature ejaculation". ^ "Priligy is used to Treat Premature Ejaculation".

Safety and tolerability

In May 2012, US-based Furiex Pharmaceuticals reached an agreement with ALZA Corp and Janssen Pharmaceuticals to market dapoxetine in the United States, Japan, and Canada, while selling the rights to market the drug in Europe, most of Asia, Africa, Latin America, and the Middle East to Menarini. Randomized, double-blind, placebo-controlled trials have confirmed the efficacy of dapoxetine for the treatment of PE. [10] Different dosages have different impacts on different types of PE. Dapoxetine 60 mg significantly improves the mean intravaginal ejaculation latency time (IELT) compared to that of dapoxetine 30 mg in men with lifelong PE, but no difference is seen in men with acquired PE. [11] Dapoxetine, given 1–3 hours before sexual episode, prolongs IELT and increases the sense of control and sexual satisfaction in men of 18 to 64 years of age with PE.

Serious side effects

Since PE is associated with personal distress and interrelationship difficulty, dapoxetine provides help for men with PE to overcome this condition. With no drug approved specifically for treatment for PE in the US and some other countries, other SSRIs such as fluoxetine, paroxetine, sertraline, fluvoxamine, and citalopram have been used off-label to treat PE. Waldinger's meta-analysis shows that the use of these conventional antidepressants increases IELT two- to nine-fold above baseline, compared to three- to eight-fold when dapoxetine is used. [11] However, these SSRIs may need to be taken daily to achieve meaningful efficacy, and their comparatively longer half-lives increase the risk of drug accumulation and a corresponding increase of adverse effects such as reduced libido. [13] Dapoxetine, though, is generally categorized as a fast-acting SSRI.